Figure 4. Baseline ferritin level and post-V1 white blood cell count (WBC) are clinical predictors of post-V2 antibody responses in maintenance hemodialysis (HD) patients.

(A) Ferritin levels associated with lowest all-cause mortality predict the development of higher anti-spike IgG after vaccination at V2D7 (p<0.01) and M6 (not shown, p<0.05) in maintenance HD patients. Dashed vertical lines indicate the intermediate range of ferritin (200–1200 ng/ml) associated with lowest all-cause mortality (Kalantar-Zadeh et al., 2005). (B) Increased WBC after first vaccination dose is predictive of anti-spike IgG titers after vaccination at V2D7 (p<0.01) and M6 (not shown, p<0.05) in maintenance HD patients. Points with negative log-fold change of white blood cell counts (LFC(WBC)) and positive LFC(WBC) represent a decrease and increase, respectively, in WBC from baseline labs.