Figure 4.

Assessment of the extent to which elevated nonfasting blood glucose levels caused by feeding of high-fat meals in ZDF rats can return to normal glycemia levels after reversal to normal diets for 2 weeks. The first three data points refer to nonfasting glucose levels during feeding with regular diet. Subsequent data refer to glucose levels after initiation of high-fat diet at time zero. The three different-colored lines after time zero represent the animals that were fed high-fat diets for specific times (9,18, or 28 days [d]) and then reversed (R) to normal diets for 2 weeks before sacrifice. Data represent four animals at each time point (mean ± SE).