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. 2024 Apr 24;15:3302. doi: 10.1038/s41467-024-47004-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Volcano plot illustrating significantly downregulated (blue symbols) and upregulated (orange symbols) proteins, by treatment of primary human dermal fibroblasts with 40 μM P2 + P5 for 20 h in serum-free conditions in comparison to control samples. Unpaired two-sided Student´s t-test, S₀ = 0.1, N = 3 independent samples. B Gene ontology (GO) terms of proteins affected by peptide treatment. Box plot represents the median, 25^th and 75^th percentiles, max. and min. are connected through whiskers. Outliers are defined as Q₁−1.8 interquartile range (IQR) and Q₃ + 1.8 IQR. An unpaired two-sided Student´s test was performed.