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. 2024 Apr 24;14:9458. doi: 10.1038/s41598-024-60049-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of association between the level of %LOY and cell types located in different types of tissues. (A) Association between the level of %LOY detected in tumor and uninvolved margin (UM) obtained from men diagnosed with primary tumors of CRC and described in Table 1. (B) Association between the level of %LOY detected in tumor and Tregs obtained from men diagnosed with CRC. Shaded areas indicate 95% confidence intervals. The correlation between %LOY CD45 + cells in tumor and LOY Th cells (depleted of Tregs) in blood is not shown because detected %LOY for all subjects was at 0 (zero) in these cells.