Figure 4.

Single-cell transcriptomics studies both in mouse and human microglia, conducted across various stages of development, aging, and in the context of several brain diseases such as demyelination and remyelination pathologies, glioma, ischemic stroke, and subarachnoid hemorrhage, have shed light on the molecular diversity of microglial cells. These studies have helped us to understand the transcriptomic similarities (highlighted in green) and differences (highlighted in black) between mice and humans in healthy and diseased brains. Moreover, comparisons were made between mouse microglial gene expression during ischemic stroke and subarachnoid hemorrhage, and the transcriptional profile of other disease-associated microglia, proving insights into shared molecular responses across different contexts (highlighted in red). Created by Biorender.