TABLE 4.

Human equivalent exposure concentrations predictions using MPPD-PBPK modeling and the MEC values reported in Figures 4–6 and typical cigarettes and HTP nicotine content for comparison.

	MEC (µmol)	HEC (mg nicotine/stick) median (5th-95th percentiles)	Nicotine concentration (mg nicotine/stick)	Margin of exposure (MOE)
1R6F	0.072	0.288 (0.25–0.337) a	1.85	0.16
HTP	0.77	3.05 (2.64–3.58) a	1.03	2.96

^a Monte-Carlo simulations were performed with 1,000 iterations as described in model evaluation.