TABLE 5.

Plasma concentrations of nicotine are predicted using MPPD-PBPK modeling, and the HEC values reported in Table 4 and blood concentrations predicted after exposure to the classic nicotine content.

	HEC (mg nicotine/cig)	Plasma concentration after 1 stick (ng/mL) a	HEC at steady state (mg nicotine/10 sticks)	Plasma concentration at steady state (ng/mL) a
1R6F	0.288	4.16 (1.84–10.02)	2.88	9.38 (4.34–21.42)
1R6F	1.85 b	28.18 (11.85–65.74)	18.5	60.83 (27.17–139.80)
HTP	3.05	46.48 (20.09–110.98)	30.5	101.43 (46.01–228.11)
HTP	1.03 b	15.50 (6.47–38.79)	10.3	34.30 (15.32–77.45)

^a Median (fifth-95th percentile).

^b Nicotine concentration in the Smoke/Aerosol from cigarettes or HTP sticks.