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. 2024 Apr 11;15:1375112. doi: 10.3389/fphar.2024.1375112

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Copyright © 2024 Li, Wei, Zhang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular landscape of three IDH wild-type GBM subtypes. (A) Tumor immune microenvironment (TIME): heatmap showing the immune profile in the IDH wild-type GBM subtypes (TCGA for left; G-SAM for right), with the top panel showing the expression of genes involved in immune checkpoint targets and the bottom panel showing the enrichment level of 24 microenvironment cell types. The immune enrichment score and stromal enrichment score are annotated at the top of the heatmap. (B) Epigenetic landscape: heatmap showing regulon activity profiles for GBM transcription factors (top panel) and potential regulators associated with histone modification (bottom panel) in the IDH wild-type GBM subtypes (TCGA on the left; G-SAM on the right).