Table 1.

The WHO disease classification and treatment according to severity (extracted from WHO Therapeutics and COVID-19 11th version, dated 14 July 2022)

	Non-severe	Severe	Critical
Disease severity	Absence of signs of severe or critical disease	Oxygen saturation <90% Signs of pneumonia Signs of severe respiratory distress	Requires life-sustaining treatment Acute respiratory distress syndrome Sepsis Septic shock
Interventions
Strong recommendation in favour	Nirmatrelvir and ritonavir	Corticosteroids IL-6 receptor blockers or baricitinib (depending on availability as well as clinical and contextual factors)
Weak or conditional recommendations in favour	Molnupiravir Sotrovimab Remdesivir Casirivimab and imdevimab*	Casirivimab and imdevimab

*If rapid viral genotyping is available and confirms infection with a susceptible SARS-CoV-2 variant.