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. 2024 Apr 22;12(4):e008185. doi: 10.1136/jitc-2023-008185

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Definition and prevalence of CD8 immunophenotype categories. (A) CD8-inflamed was defined with IE2+IE3≥20%. CD8-excluded was defined with ITS2+ITS3>20% and IE0+IE1≥80%. CD8-desert was defined with IE0+IE1≥80% and ITS0+ITS1≥80%. Prevalence of immunophenotype by (B) indication and (C) tumor excision location. The “Other mets” category refers to excision sites of minor frequency (each n≤4): abdominal cavity, sinus, adrenal gland, pleura, skin and soft tissue. Tumor types with n<5 samples (25 different categories, eg, bone, fallopian tube, pelvis, thymus, testis; most of them n=1) are not included. CRC, colorectal cancer; HNC, head and neck carcinoma; IE, intraepithelial; ITS, intrastromal; LN, lymph node; mets, metastases; NSCLC, non-small-cell lung cancer; UBC, urinary bladder cancer.