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. 2024 Apr 22;12(4):e008185. doi: 10.1136/jitc-2023-008185

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Inflamed, excluded and desert samples show distinct transcriptional profiles. (A) Heatmap showing relative signature scores per sample, sorted according to CD8 immunophenotype and “interferon gamma” signature scores; cancer types are displayed. (B) Selected signature scores across CD8 immunophenotype classes. “H_” represents pathway-specific signatures (Hallmark), while “sc_” represents cell-type specific signatures. *p≤0.05. **p≤0.01. ***p≤0.001. ****p≤0.0001. CRC, colorectal cancer; IHC, immunohistochemistry; ns, not significant; NSCLC, non-small-cell lung cancer; UBC, urinary bladder cancer.