Figure 2.

(A) Dot plot showing proportion of repertoire occupied by T cell clone in peripheral blood versus muscle biopsy from patient 1. (B) As for (A) but comparing the tumor from patient 3 with the muscle from patient 1. (C) A Venn diagram of the TCR overlap between cardiac and skeletal muscle of patient 3 and skeletal muscle of patient 1. (D) Morisita-Horn (MH) index for the repertoire overlap between the resected tumor from patient 3 and the skeletal muscle of patient 1, and samples taken from patients with IIM.18 (E) OR for occurrence of epitope-specific clones (TCR) found in the muscle versus the peripheral blood of patient 1. (F) As per (E) but taking into account number of copies of each clone (thereby considering clonal expansion). Statistics are via the Kolmogorov-Smirnov test (D) or Fisher’s exact test (E, F). IIM, idiopathic inflammatory myositis.