Table 2. Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) for animal studies.

Type of bias	Domain	Issler et al., 2014 [25]	Patrício et al., 2020 [49]	Lo Iacono et al., 2021 [50]	Zhang et al., 2015 [51]	Song et al., 2019 [52]	Xie et al., 2019 [53]	Grieco et al., 2017 [54]
Selection bias	Sequence generation	No	Unclear	Unclear	Unclear	Yes	No	No
	Baseline characteristics	Yes	Yes	Yes	Yes	No	Yes	Yes
	Allocation concealment	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear
Performance bias	Random housing	Yes	Yes	Yes	Yes	Unclear	Yes	Yes
	Blinding	Unclear	Yes	Unclear	Yes	Unclear	Unclear	Unclear
Detection bias	Random outcome assessment	Unclear	Unclear	Unclear	Yes	Unclear	Unclear	Unclear
	Blinding	Yes	Yes	Yes	Yes	Unclear	Yes	Yes
Attrition bias	Incomplete outcome data	Unclear	Unclear	Unclear	Unclear	Yes	No	Unclear
Reporting bias	Selective outcome reporting	Unclear	Yes	Yes	Yes	Yes	Unclear	Yes
Other	Other sources of bias	Yes	Yes	Unclear	Yes	Yes	Unclear	Yes

Type of bias	Domain	Wan et al., 2018 [55]	Mingardi et al., 2021 [56]	Huang et al., 2021 [57]	Pan et al., 2015 [58]	Higuchi et al., 2016 [59]	Zheng et al., 2023 [60]	Guan et al., 2023 [61]
Selection bias	Sequence generation	Unclear	Unclear	No	Yes	No	Unclear	Unclear
	Baseline characteristics	Yes	Yes	Yes	No	Yes	Yes	Yes
	Allocation concealment	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear
Performance bias	Random housing	No	Yes	Yes	Unclear	Unclear	Yes	Unclear
	Blinding	No	Yes	Unclear	Unclear	Unclear	Unclear	Unclear
Detection bias	Random outcome assessment	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear
	Blinding	Yes	Yes	Unclear	Yes	Yes	Unclear	Unclear
Attrition bias	Incomplete outcome data	Unclear	No	No	Yes	Unclear	Unclear	Unclear
Reporting bias	Selective outcome reporting	Yes	Yes	Yes	Yes	Yes	Yes	Unclear
Other	Other sources of bias	Yes	Yes	Yes	Yes	Yes	Yes	Yes