Table 5. Summary of four studies investigating miRNA expression in human cell cultures after ADs use.

Abbreviations: LCLs - human lymphoblastoid cell lines, miRNA - microRNA

Author/year	Population	Treatment	Sample	MicroRNAs after treatment
Lopez et al. [14], 2017 (Canada)	Human neural progenitor cells	Duloxetine	Human neural progenitor cells	Reduced: miR-146a-5p, miR-146b-5p, miR-24-3p, and miR-425-3p
Oved et al. [62], 2012 (Israel)	LCLs from 80 healthy adult female donors	Paroxetine	LCLs	MiR-151-3p: increased sensitivity to paroxetine MiR-212, miR-132, miR-30b*, let-7b and let-7c also differed between paroxetine and control groups
Angelucci et al. [63], 2011 (Italy)	Cell cultures and control cultures	Paroxetine	Human glioblastoma-astrocytoma;	6 h and 12 h of incubation Increased: miR-30a 24h of incubation: miR-30a expression returned to levels comparable to untreated cells
Oved et al. [64], 2013 (Israel)	Cell cultures and control cultures	1mM paroxetine for 21 days X phosphate-buffered saline	Cell cultures (human)	Reduced: miR-221 and miR-22