Fig. 4.

Differential expression of genes involved in antiviral responses in Mfs and DCs after Bifidobacterium animalis subsp. lactis Bl-04 or pIC + R848 treatment. Cells were stimulated with Bl-04 (10 bacteria/cell) or pIC (15 μg/ml) + R848 (5 μM) for 24 h (Mf) or 48 h (DC). RNA was collected and transcriptomic analyses were performed. Selected genes of interest were grouped to (A) Receptor, (B) PRR, (C) Signaling, (D) Interferon, (E) Chemokine, (F) Cytokine and (G) Antiviral protein categories. Color of the balloon denotes expression level (log2 fold change) with blue having reduced expression and red having increased expression compared with the control. Size of the balloon denotes significance (-log10 adjusted p-value, black outline at adjusted p-value <0.05) with the larger size having more significance. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)