Table 3. Post Hoc Sensitivity Analysis of Primary and Secondary Outcomes Weighted to Reflect Original Antenatal Late Preterm Steroids Trial Populationa.
| Outcome | No. (%) | Inverse probability weighting, relative risk (95% CI)b | ||
|---|---|---|---|---|
| Betamethasone | Placebo | Unadjusted | Adjustedc | |
| Primary outcome | (n = 1315) | (n = 1305) | ||
| DAS-II General Conceptual Ability <85d | 238 (18.1) | 266 (20.3) | 0.89 (0.67 to 1.16) | 0.92 (0.71 to 1.25) |
| Secondary outcomes | (n = 1430) | (n = 1402) | Relative risk (95% CI) | |
| Social Responsiveness Scale t-score >65, No./total (%)e | 203/1416 (14.3) | 218/1402 (15.5) | 0.92 (0.66 to 1.28) | 0.92 (0.67 to 1.32) |
| >Level I Gross Motor Function Classification Systemf | 3 (0.2) | 3 (0.2) | ||
| Child Behavior Checklistg | Mean difference | |||
| Total problems t score | 48.8 (18.2) | 49.5 (18.8) | −0.70 (−2.16 to 0.73) | −0.91 (−2.23 to 0.51) |
Comparison of original cohorts and cohorts remaining at 6 years or older, including corrections with weighting, are shown in eTable 3 in Supplement 1.
Inverse probability weighting accounts for maternal age, insurance status, and smoking status during pregnancy. Data are relative risk (95% CI) for categorical outcomes and mean difference (95% CI) for continuous outcomes.
Adjusted for gestational age at delivery, child age, sex, and center.
The Differential Ability Scales 2nd Edition (DAS-II) General Conceptual Ability score has a mean (SD) of 100 (15); scores 85 or higher are average and less than 85, below average, with higher scores indicating greater abilities.
Score range: less than 60, normal; 60 to 65, mild; 66 to 75, moderate; and 76 or higher, severe, with higher scores indicating greater problems.
There are 5 levels with greater functional impairment at increasing levels: walks without limitations, walks with limitations, walks with handheld mobility device, self-mobility with limitations; may use powered mobility, and transported in a manual wheelchair.
Score range: less than 60, normal; 60 to 63, borderline (84th-90th percentile); and 64 or higher clinical (>90th percentile), with higher scores indicating greater problems.