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. 2024 Apr 9;9(16):18212–18223. doi: 10.1021/acsomega.3c10399

Table 3. Composition and Content (Ratio/g) of Low-Molecular-Weight Metabolites in the Plasma of Mice.

  contents (average ± SD, ratio/g)
compound sham OVX E2
pyruvic acid 1.56 ± 0.56 2.11 ± 0.22 2.42 ± 0.45
lactic acid 81.77 ± 15.37 63.54 ± 7.47 67.6 ± 3.78
alanine 33.03 ± 6.57 23.6 ± 2.60 32.08 ± 4.00
oxalic acid 80.55 ± 22.78 60.6 ± 2.47 59.32 ± 4.47
hydroxybutanoic acid 0.93 ± 0.40 1.31 ± 0.42 1.56 ± 0.27
valine 9.42 ± 2.43 8.47 ± 1.05 17.18 ± 1.33
urea 76.7 ± 14.02 74.14 ± 8.94 95.86 ± 6.85
serine 1.13 ± 0.38 0.83 ± 0.26 0.83 ± 0.25
ethanolamine 0.58 ± 0.13 1.18 ± 0.19 1.31 ± 0.11
glycerol 11.70 ± 1.67 14.68 ± 1.12 13.34 ± 1.96
phosphoric acid 12.4 ± 4.82 10.54 ± 2.34 12.81 ± 2.34
leucine 6.42 ± 1.28 5.67 ± 0.97 12.53 ± 1.85
isoleucine 3.84 ± 0.73 3.20 ± 0.41 7.26 ± 0.95
proline 3.84 ± 1.75 2.79 ± 0.72 8.18 ± 1.41
glycine 4.62 ± 0.78 9.33 ± 1.61 13.87 ± 2.67
succinic acid 2.31 ± 2.20 1.15 ± 0.37 1.42 ± 0.27
fumaric acid 0.23 ± 0.12 0.22 ± 0.04 0.25 ± 0.06
threonine 0.59 ± 0.20 0.44 ± 0.08 0.89 ± 0.17
β-alanine 0.01 ± 0.00 0.02 ± 0.00 0.02 ± 0.00
malic acid 1.44 ± 0.69 1.30 ± 0.28 1.63 ± 0.33
aspartic acid 0.12 ± 0.03 0.11 ± 0.04 0.17 ± 0.02
methionine 1.67 ± 0.44 1.17 ± 0.24 2.19 ± 0.58
pyroglutamic acid 9.10 ± 0.98 10.76 ± 1.24 11.16 ± 0.53
cysteine 0.16 ± 0.04 0.14 ± 0.02 0.21 ± 0.03
glutamic acid 0.62 ± 0.14 0.59 ± 0.12 0.63 ± 0.11
phenylalanine 1.95 ± 0.24 1.52 ± 0.15 2.35 ± 0.24
asparagine 0.56 ± 0.16 0.35 ± 0.03 0.53 ± 0.11
xylitol 0.09 ± 0.04 0.05 ± 0.01 0.07 ± 0.01
ribitol 0.05 ± 0.01 0.05 ± 0.00 0.05 ± 0.00
glutamine 7.76 ± 1.19 8.23 ± 0.77 7.24 ± 0.26
citric acid 1.91 ± 0.30 1.86 ± 0.14 1.71 ± 0.09
fructose 0.38 ± 0.06 0.40 ± 0.04 0.47 ± 0.12
mannose 1.48 ± 0.41 1.76 ± 0.11 1.26 ± 0.26
glucose 75.27 ± 18.19 55.57 ± 1.27 50.24 ± 2.68
lysine 1.29 ± 0.29 1.45 ± 0.13 1.96 ± 0.32
C16:1 (palmitoleic acid) 0.06 ± 0.02 0.09 ± 0.03 0.04 ± 0.02
C16:0 (palmitic acid) 1.54 ± 0.33 1.19 ± 0.09 0.97 ± 0.11
inositol 2.31 ± 0.14 2.77 ± 0.33 3.30 ± 0.48
C18:2 (linoleic acid) 0.20 ± 0.05 0.12 ± 0.01 0.10 ± 0.02
C18:1n9 (oleic acid) 0.36 ± 0.10 0.27 ± 0.05 0.18 ± 0.04
tryptophan 5.70 ± 0.62 6.04 ± 0.54 5.66 ± 0.82
C18:0 (stearic acid) 0.94 ± 0.20 0.61 ± 0.13 0.53 ± 0.12
sucrose 0.03 ± 0.01 0.04 ± 0.02 0.04 ± 0.01
cholesterol 5.43 ± 1.70 3.54 ± 0.30 3.80 ± 0.32