. 2024 Apr 10;9(16):17817–17831. doi: 10.1021/acsomega.3c07133

Table 3. Conditions’ Optimization of the Model Heck Reaction between Iodobenzene and Styrene^a.

entry	solvent	base	catalyst (mol %)	yield (%)
1	ACN	Et₃N	0.34	11
2	EtOH	Et₃N	0.34	trace
3	EtOH/H₂O (v/v, 2:1)	Et₃N	0.34	trace
4	toluene	Et₃N	0.34	5
5	DMF	Et₃N	0.34	80
6	DMF/H₂O (v/v, 2:1)	Et₃N	0.34	20
7	DMF	K₂CO₃	0.34	70
8	DMF	Na₂CO₃	0.34	59
9	DMF	NaOAc	0.34	44
10	DMF	NaHCO₃	0.34	50
11	DMF	KOH	0.34	6
12	DMF	Et₃N	0	0
13	DMF	Et₃N	0.50	85
14	DMF	Et₃N	0.80	90
15	DMF	Et₃N	1.00	99
16	DMF	Et₃N	1.50	95

Conditions: 0.5 mmol iodobenzene, 0.75 mmol styrene, 1 mmol base, 120 °C, 7 h.

Table 3. Conditions’ Optimization of the Model Heck Reaction between Iodobenzene and Styrenea.