Table 3.
Univariable and multivariable analyses for the risk factors of overall response and survival
| Parameters | Overall response at day 10 after treatment | Overall survival | Failure-free survival | |||
|---|---|---|---|---|---|---|
|
Univariable OR (95%CI) P value |
Multivariable OR (95%CI) P value |
Univariable HR (95%CI) P value |
Multivariable HR (95%CI) P value |
Univariable HR (95%CI) P value |
Multivariable HR (95%CI) P value |
|
|
Gender female vs male |
1.92(0.70–5.24); .20 |
- |
1.30(0.36–4.62); .67 |
- |
0.74(0.46–1.21); .23 |
- |
|
Patient age < 35 vs ≥ 35 years (median) |
1.05(0.39–2.82); .90 |
- |
0.40(0.10–1.55); .18 |
- |
1.18(0.72–1.92); .49 |
- |
|
MAGIC criteria grade I-II vs III-IV |
17.18(4.67–63.16); * < .001 |
20.12(4.28–94.37); * < .001 |
0.18(0.04–0.73); *.016 |
0.18(0.04–0.73); *.016 |
0.22(0.11–0.45); * < .001 |
0.26(0.13–0.52); * < .001 |
|
GVHD risk category standard vs high |
29.06(6.57–128.35); * < .001 |
- |
0.15(0.03–0.58); *.006 |
- |
0.19(0.09–0.40); * < .001 |
- |
|
Underlying malignancy AML/MDS vs ALL or others |
0.79(0.281–2.24); .66 |
- |
2.46(0.52–11.61); .25 |
- |
1.20(0.72–2.00); .47 |
- |
|
Graft source PB vs BM |
0.96(0.25–3.60); .96 |
- |
1.85(0.23–14.60); .55 |
- |
0.71(0.39–1.29); .26 |
- |
| Donor source | .71 | - | .43 | - | .33 | - |
| Matched sibling |
0.56(0.14–2.20); .41 |
0.00 .98 |
1.45(0.74–2.83); .27 |
|||
| Unrelated donor |
0.00 .99 |
2.72(0.59–12.72); .20 |
1.56(0.71–3.41); .26 |
|||
| Haplo donor | 1.0 | 1.0 | 1.0 | |||
|
Center Peking university vs others |
1.47(0.48–4.46); .49 |
- |
2.61(0.33–20.66); .36 |
- |
0.92(0.52–1.64); .79 |
- |
|
Mini-dose MTX treatment MTX vs control |
8.90(1.96–40.41); *.005 |
9.39(1.81–48.59); *.008 |
0.78(0.21–2.91); .71 |
- |
0.46(0.27–0.76); * .002 |
0.49(0.30–0.82); *.007 |
Abbreviations: OR Odds ratio, HR Hazard ratios, CI Confidence interval, MAGIC Mount Sinai Acute GVHD International Consortium, GVHD Graft-versus-host disease, AML Acute myeloid leukemia, MDS Myelodysplastic syndrome, ALL Acute lymphoid leukemia, PB Peripheral blood, BM Bone marrow
*P < .05