Fig. 6.

Motor function. Female rats traveled farther in the open field than males (A). No effect of CIH or MT was observed in the open field (A). Distance traveled in the MOF was dependent on CIH, sex, and MT (B). CIH decreased MOF distance traveled in vehicle females, which was prevented by MT (B). CIH MT females had elevated MOF distance traveled compared to both normoxic vehicle males, and CIH MT males (B). In normoxic males, MT increased MOF distance traveled, but this effect was not seen in CIH males (B). Data for MOF distance traveled was log transformed for analysis. Raw values are shown and error bars denote mean ± S.E.M. Analyzed by 3-way ANOVA with Fisher’s LSD multiple comparisons tests. ANOVA significance indicated by: **p ≤ 0.01; Post-hoc significance indicated by unique letters (p ≤ 0.05). Significant effect observed (A): Sex (F_{1, 60} = 10.598; p = 0.002; η² = 0.136). Significant effects observed (B): CIH (F_{1, 64} = 4.706; p = 0.034; η² = 0.058); CIH X Sex X MT (F_{1, 64} = 6.683; p = 0.012; η² = 0.083). CIH chronic intermittent hypoxia, MOF modified open field, MT MitoTEMPOL