Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 24;19:38. doi: 10.1186/s13024-024-00726-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Influence of APOE status on peripheral immunity in AD patients. a Violin plots displaying the percentage of the annotated immune cell population out of the total CD45⁺ immune population using a GLM with age and sex as covariates in different APOE genotypes across the AD continuum. b Stacked bar graphs showing the percentage of T cell and CD4⁺ T cells subpopulations out of the total T cell and CD4⁺ T cell populations. c Volcano plots displaying differentially expressed genes (P_unadjusted < 0.05) between different APOE genotypes in AD. Red and blue indicate respectively higher and lower expression. d Violin plots displaying the expression of the two genes that were differentially expressed in both APOE ε4ε4 and APOE ε3ε4 compared to the APOE ε3ε3 carriers. e Correlation matrix showing the association between immune cell populations with CSF biomarkers of AD neuropathology or cognition. A partial two-tailed Spearman correlation was performed and controlled for age and sex. f, g Correlation graph showing correlations of CD27⁺ B cells with CSF Aβ42 (f) and MMSE (g). a, d Violin plots showing median ± quartiles. f, g Graph shows linear regression ± 95% confidence intervals. n = 12 ε3ε3 AD, n = 12 ε3ε4 AD, n = 12 ε4ε4 AD. GLM = multivariate general linear model; AD = Alzheimer’s disease