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Power comparisons of aggregate LIT (aLIT; black), unweighted LIT (uLIT; blue), and weighted LIT (wLIT; green) under A positive pleiotropy and B a mixture of positive and negative pleiotropy. The simulation study varied the correlation between traits (columns), the number of traits (rows), and the proportion of traits with an interaction term (x-axis) at a sample size of 300,000. The points represent the average across 500 simulations with a significance threshold of
