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. 2024 Apr 25;16:62. doi: 10.1186/s13073-024-01329-0

Fig. 3.

Fig. 3

A comparison of aLIT (black) to a marginal testing procedure using the squared residuals (SQ; light gray) and a marginal testing procedure using the squared residuals and cross products (SQ/CP; dark gray) under A positive pleiotropy and B a mixture of positive and negative pleiotropy. The simulation study is identical to Fig. 2 where the empirical power is calculated as a function of the proportion of traits with an interaction term (x-axis), the number of traits (rows), and trait correlation (columns)