Table 1.

aLIT and Marginal (SQ/CP) significance results of the lead SNPs from the UK Biobank analysis. There are two other p-values reported to help assess statistical significance in aLIT: (i) accounting for significant SNPs in linkage disequilibrium with the lead SNP (labeled “LD”) and (ii) removing dominance and/or scaling effects (labeled “Dom.”)

Chr.	Gene	Lead SNP	MAF	p-value (aLIT)	p-value (SQ/CP)	p-value (LD)	p-value (Dom.)
16	FTO	rs11642015	0.402	$1.08\times {10}^{-46}$	$2.73\times {10}^{-40}$	$1.23\times {10}^{-46}$	$1.28\times {10}^{-46}$
2	COBLL1	rs5835988	0.406	$5.30\times {10}^{-14}$	$1.08\times {10}^{-9}$	$1.29\times {10}^{-13}$	$5.32\times {10}^{-14}$
1	LYPLAL1	rs2820444	0.299	$1.17\times {10}^{-13}$	$2.64\times {10}^{-13}$	$1.27\times {10}^{-13}$	$1.19\times {10}^{-13}$
6	PRSS16	rs13212921	0.136	$1.78\times {10}^{-13}$	$3.40\times {10}^{-12}$	$1.90\times {10}^{-12}$	$4.85\times {10}^{-9}$
18	MC4R	rs35614134	0.234	$3.95\times {10}^{-12}$	$9.34\times {10}^{-12}$	$1.39\times {10}^{-11}$	$3.97\times {10}^{-12}$
1	ATP2B4	rs2821230	0.474	$9.45\times {10}^{-11}$	$1.19\times {10}^{-5}$	$1.02\times {10}^{-10}$	$9.38\times {10}^{-11}$
7	KLF14	rs972284	0.389	$1.43\times {10}^{-10}$	$2.43\times {10}^{-9}$	$1.25\times {10}^{-10}$	$1.43\times {10}^{-10}$
11	LIN7C	rs11030066	0.143	$6.38\times {10}^{-10}$	$5.03\times {10}^{-6}$	$6.97\times {10}^{-10}$	$6.62\times {10}^{-10}$
6	ILRUN	rs9469860	0.146	$1.01\times {10}^{-9}$	$4.47\times {10}^{-9}$	$7.72\times {10}^{-9}$	$3.62\times {10}^{-7}$
12	FAIM2	rs7132908	0.384	$8.85\times {10}^{-9}$	$4.22\times {10}^{-9}$	$8.49\times {10}^{-9}$	$8.96\times {10}^{-9}$
5	MAP3K1	rs157845	0.253	$1.03\times {10}^{-8}$	$2.39\times {10}^{-4}$	$1.30\times {10}^{-8}$	$1.03\times {10}^{-8}$