Table 2.

Potential utilizing of nanozymes in dental implant

Nanozymes	Antibacterial mechanism	Reference
CuN4-CNS	The findings obtained from both in vitro and in vivo experiments indicate that the ideal CuN4-CNS has great therapeutic effectiveness in treating both deep implant-related biofilm infections and superficial skin wounds by successfully inhibiting multidrug-resistant bacteria and eliminating recalcitrant biofilms	[68]
Fe-NC@TNT	Fe-NC@TNT was examined for its physical composition, surface morphology, enzyme-like catalytic activity, inflammatory response, and compatibility with soft tissues.Fe-NC@TNT has also been shown in vivo animal trials to successfully control the immune response and facilitate the integration of the implant with the surrounding soft tissues	[114]
TNT-ZIF-67@OGP	The TNT-ZIF-67@OGP demonstrated potent antibacterial efficacy against S. aureus, MRSA, E. coli, and S. mutans due to ZIF-67 NP hydrolysis and the creation of an alkaline microenvironment	[115]
BIONPs	Reports a new "interference-regulation strategy" for fighting BAIs that uses bovine serum albumin-iridium oxide NPs (BIONPs) as an immunomodulator and biofilm homeostasis interrupter via singlet oxygen (1O2)-sensitized mild hyperthermia	[116]
Cu2MoS4	pH-responsive enzyme-like activities were used to construct multifunctional smart hollow Cu2MoS4 nanospheres (H-CMS NSs) that can self-adapt to eliminate biofilms and control macrophage inflammation in implant infections	[117]
Cu-CDs/H2O2	Antibacterial properties against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, preventing wound purulent infection and accelerating wound healing. In addition, the Cu-CDs/H2O2 system exhibits superior tooth whitening performance compared to other alternatives, such as clinically utilized H2O2 and CDs, due to its negligible enamel and dentin degradation	[118]