Fig. 4 –

miRNA expression is significantly altered after MSC administration in TAA tissue. (A) Heat map of significant differences in miRNAs expression between murine aortic tissue from controls (saline treated) and elastase treated mice (TAA) demonstrating significantly different miRNAs profiles in the development of TAA. (B) Heat map of significantly altered miRNAs profile of mice aortic tissue between TAA and TAA + MSCs. (C) Differential expression of miRNAs that are significantly altered during TAA formation between elastase-treated mice and saline controls. (D) Differential expression of miRNAs that are significantly altered after MSC administration in elastase-treated mice compared to untreated elastase controls (TAA). n = 5 mice/group. miRNA = microRNAs; MSC = mesenchymal stem cell; TAA = thoracic aortic aneurysms;