TABLE 1.
Baseline patient and tumor characteristics
| Bone Marrow Metastatic | ||
|---|---|---|
|
| ||
| Variable | Number | (%) |
|
| ||
| Total Number Patients | 179 | 100 |
|
| ||
| Age median, range | 14.8 (0.02, 26.3) | |
|
| ||
| Sex | ||
|
| ||
| Male | 103 | 57.5 |
|
| ||
| Female | 76 | 42.5 |
|
| ||
| Age at diagnosis, years | ||
|
| ||
| < 1 | 3 | 1.7 |
|
| ||
| 1 – 9 | 47 | 26.3 |
|
| ||
| ≥ 10 | 129 | 72.1 |
|
| ||
| Race | ||
|
| ||
| Nonwhite | 29 | 16.2 |
|
| ||
| White | 132 | 73.7 |
|
| ||
| Unknown | 18 | 10.1 |
|
| ||
| Histology Subtype | ||
|
| ||
| Alveolar | 136 | 76.0 |
|
| ||
| Alveolar Fusion Status | ||
| Positive FOXO1 Fusion | 68 | 50.0 |
| PAX3-FOXO1 | 47 | 69.1 |
| PAX7-FOXO1 | 5 | 7.4 |
| Unknown Partner-FOXO1 | 16 | 23.5 |
| Negative FOXO1 Fusion | 3 | 2.2 |
| Unknown Fusion Status | 65 | 47.8 |
|
| ||
| Embryonal | 25 | 14.1 |
|
| ||
| Spindle cell | 1 | 0.6 |
|
| ||
| Other | 17 | 9.5 |
|
| ||
| Primary Site | ||
|
| ||
| Extremity | 57 | 31.8 |
|
| ||
| Retroperitoneal | 25 | 14.0 |
|
| ||
| Trunk/paravertebral | 18 | 10.1 |
|
| ||
| Bladder/Prostate | 15 | 8.4 |
|
| ||
| Parameningeal | 14 | 7.8 |
|
| ||
| Perineum | 13 | 7.3 |
|
| ||
| GU non-Bladder/Prostate | 12 | 6.7 |
|
| ||
| Other | 9 | 5.0 |
|
| ||
| Head and Neck, Non-Parameningeal | 7 | 3.9 |
|
| ||
| Unknown | 7 | 3.9 |
|
| ||
| Intrathoracic | 1 | 0.6 |
|
| ||
| Orbit | 1 | 0.6 |
|
| ||
| Tumor Invasiveness | ||
|
| ||
| T1 | 11 | 6.2 |
|
| ||
| T2 | 167 | 93.3 |
|
| ||
| Unknown | 1 | 0.6 |
|
| ||
| Tumor Size, cm | ||
|
| ||
| ≤ 5 | 51 | 28.5 |
|
| ||
| >5 | 128 | 71.5 |
|
| ||
| Regional Lymph Node | ||
|
| ||
| N0 | 51 | 28.5 |
|
| ||
| N1 | 118 | 65.9 |
|
| ||
| Nx | 10 | 5.6 |
|
| ||
| Number of Metastatic Sites | ||
|
| ||
| 1 – Bone marrow Only | 22 | 12.3 |
|
| ||
| 2 | 46 | 25.7 |
|
| ||
| ≥ 3 | 110 | 61.5 |
|
| ||
| missing | 1 | 0.6 |
|
| ||
| Additional Metastatic Sites | ||
|
| ||
| Bone | 100 | 55.9 |
|
| ||
| Lung | 70 | 39.1 |
|
| ||
| Lymph node | 81 | 45.3 |
|
| ||
| Oberlin Score | ||
|
| ||
| 1 | 10 | 5.6 |
|
| ||
| 2 | 34 | 19.0 |
|
| ||
| 3 | 65 | 36.3 |
|
| ||
| 4 | 63 | 35.2 |
|
| ||
| Missing/Not calculable | 7 | 3.9 |