FIGURE 3.

Regression model for the interrelationship of amyloid beta (Aβ) oligomers pixel count, Aβ42, and phosphorylated tau (pTau) in cerebrospinal fluid (CSF). Based on Aβ42, pTau, and Aβ oligomer levels in CSF, regression models for prediction of Aβ oligomers pixel count were performed. Highest Aβ oligomer levels can be expected in patients with low Aβ42 while pTau is relatively low in (A) all patients, (B) apolipoprotein E (APOE) gene ε4 allele carriers, and (C) APOE ε4 noncarriers. Aβ42 oligomer levels in APOE ε4‐positive participants are overall higher and shifted toward higher pTau concentrations compared to those who were APOE ε4 negative.