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. 2024 Apr 17;22(2):106–111. doi: 10.1089/lrb.2023.0065

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© Steven Morgan et al., 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 2. — Overrepresented GO terms from filtered variants. The top GO terms are shown across the categories of (a) molecular function, (b) biological process, and (c) cellular component. The analysis was conducted using ConsensusPathDB from the total set of candidate variants. Term “ratio” is defined as the number of genes identified as belonging to a particular GO term divided by the total number of genes in that GO term. Adjusted p-values are obtained via a hypergeometric test and corrected for multiple hypothesis testing using the false discovery rate method. Dotted line shows the statistical significance threshold of Adjusted p-value = 0.05. GO, Gene Ontology.