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. 2024 Apr 16;35(7-8):256–268. doi: 10.1089/hum.2023.177

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© Fabio Catalano et al. 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — IDS activity in liver, spleen, and kidney after gene therapy. IDS enzyme activity in liver (A), spleen (B), and kidney (C). (D) Sections of liver of GFP-treated and untreated Ids^y/− mice stained with anti-GFP antibody. (E) Chimerism analysis of liver measured by allele-specific qPCR on the Cd45.1 locus. Data represent means ± SEM and were analyzed by one-way ANOVA followed by Bonferroni's multiple testing correction. Enzyme activity: IDSco, IDS.IGF2co, GFP, Ids^y/−, and WT n = 6; IDS.ApoE2co n = 10; IDS.RAP12x2co n = 7. Chimerism: n = 6. GFP staining: n = 3. **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. ^##p ≤ 0.01, ^###p ≤ 0.001, ^####p ≤ 0.0001. Asterisks represent significance versus WT; hash represent significance versus Ids^y/−. Significant results are indicated by brackets. ANOVA, analysis of variance; GFP, green fluorescent protein; qPCR, quantitative polymerase chain reaction; SEM, standard error of the mean.