Figure 3.
Gene therapy corrects pathology in liver, spleen, and kidney. Representative pictures of Alcian Blue, and LAMP1 and CD68 stainings of liver, spleen, and kidney of gene therapy-treated Idsy/− mice and controls. CD68 staining in spleen is shown in Supplementary Fig. S3. Hollow arrowheads indicate Alcian Blue-positive cells in gene therapy-treated mice. Inserts represent regions of interest magnified four times. n = 3 biological replicas. Scale bars = 100 μm. C, splenic capsule; Ed, endothelial cells; LAMP1, lysosomal-associated membrane protein 1; RC, renal capsule; T, splenic trabeculae.