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. Author manuscript; available in PMC: 2024 Apr 25.
Published in final edited form as: Front Biosci (Schol Ed). 2024 Mar 1;16(1):4. doi: 10.31083/j.fbs1601004

Fig. 3. Non-coding variants can disrupt mRNA processing and translation initiation.

Fig. 3.

(A) mRNA interactions with RNA-binding proteins and ribosomes are needed for processing (e.g., splicing and adenylation) and translation initiation, respectively. (B) Non-coding variants can alter splice and polyadenylation sites needed for stable mRNA processing and expression of functional protein isoforms. mRNA variants can create translation sites that compete with the main open reading frame (mORF). PAS, polyadenylation sites.