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Impaired antibody response against the product of the transgene in TNF-α/LTα-deficient mice. TNF-α/LTα+/+, TNF-α/LTα+/−, and TNF-α/LTα−/− mice were injected with AdRSVβgal (5 × 109 PFU). The values expressed as OD490 represent relative quantities of antibody at a serum dilution of 1:4,000 (IgG+IgM). The black triangles represent antibody levels at day 15 p.i. in the serum of individual mice, and the columns represent the mean of each group.
