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. 2024 Apr 25;19(4):e0302300. doi: 10.1371/journal.pone.0302300

Table 1. Characteristics of dementia and non-dementia groups.

Characteristic Total Dementia Non-dementia P-value*
n % n % n %
Total 867,677 (100.0) 57,346 (100.0) 810,331 (100.0)
Polypharmacy ** 0–4 524,210 (60.4) 17,028 (29.7) 507,182 (62.6) <0.0001
5–9 274,909 (31.7) 26,737 (46.6) 248,172 (30.6)
10+ 68,558 (7.9) 13,581 (23.7) 54,977 (6.8)
Sex Male 388,789 (44.8) 18,344 (32.0) 370,445 (45.7) <0.0001
Female 478,888 (55.2) 39,002 (68.0) 439,886 (54.3)
Age (mean±SD) 70.1 (7.9) 79.6 (7.0) 69.5 (7.5) <0.0001
Age range 60–64 274,239 (31.6) 2,125 (3.7) 272,114 (33.6) <0.0001
65–69 189,866 (21.9) 3,603 (6.3) 186,263 (23.0)
70–74 148,178 (17.1) 6,619 (11.5) 141,559 (17.5)
75–79 123,755 (14.3) 13,124 (22.9) 110,631 (13.7)
80–84 84,352 (9.7) 16,724 (29.2) 67,628 (8.3)
85–89 39,630 (4.6) 12,219 (21.3) 27,411 (3.4)
90–91 7,657 (0.9) 2,932 (5.1) 4,725 (0.6)
Disability Severe 30,859 (3.6) 5,286 (9.2) 25,573 (3.2) <0.0001
Mild 87,855 (10.1) 10,675 (18.6) 77,180 (9.5)
None 748,963 (86.3) 41,385 (72.2) 707,578 (87.3)
Region Seoul-Metro 385,324 (44.4) 21,743 (37.9) 363,581 (44.9) <0.0001
Chungcheong 95,723 (11.0) 7,319 (12.8) 88,404 (10.9)
Honam 101,664 (11.7) 9,493 (16.6) 92,171 (11.4)
Gyeongsang 241,936 (27.9) 15,828 (27.6) 226,108 (27.9)
Gangwon-Jeju 43,030 (5.0) 2,963 (5.2) 40,067 (4.9)
Income level Medical Aid 58,010 (6.7) 8,452 (14.7) 49,558 (6.1) <0.0001
NHI 1st 141,169 (16.3) 8,684 (15.1) 132,485 (16.3)
NHI 2nd 97,507 (11.2) 4,419 (7.7) 93,088 (11.5)
NHI 3rd 127,012 (14.6) 6,595 (11.5) 120,417 (14.9)
NHI 4th 173,556 (20.0) 9,348 (16.3) 164,208 (20.3)
NHI 5th (richest) 270,423 (31.2) 19,848 (34.6) 250,575 (30.9)
Type of long-term care benefits Institutional care 10,923 (1.3) 8,681 (15.1) 2,242 (0.3) <0.0001
Home care 36,716 (4.2) 19,036 (33.2) 17,680 (2.2)
None 820,038 (94.5) 29,629 (51.7) 790,409 (97.5)
Duration of dementia (years) <1 24,014 (41.9)
1–3 11,273 (19.7)
3–10 19,041 (33.2)
≥10 3,018 (5.3)
CCI ≤2 651,670 (75.1) 18,898 (33.0) 632,772 (78.1) <0.0001
3–4 152,305 (17.6) 20,579 (35.9) 131,726 (16.3)
≥5 63,702 (7.3) 17,869 (31.2) 45,833 (5.7)

*Chi-square or t-test of differences between dementia and non-dementia groups

**Number of concurrently prescribed medications over 90 d

SD: standard deviation, NHI: National Health Insurance, CCI: Charlson comorbidity index