Table 2.
Clinical Outcomes of Patients Eligible for Vericiguat in GWTG-HF
| Outcomes | VICTORIA Eligible Patients (GWTG-HF)* |
FDA Label Patients (GWTG-HF)* |
Hospitalized HF with EF<45% (GWTG-HF)* |
|---|---|---|---|
| In-Hospital Outcomes * | |||
| Discharge Disposition | |||
| Home | 75,494 (81.8) | 184,630 (83.3) | 198,893 (82.5) |
| Other Health Care Facility | 14,139 (15.3) | 31,629 (14.3) | 35,025 (14.5) |
| Expired | 2,616 (2.8) | 5,471 (2.5) | 7,139 (3.0) |
| In-hospital Death | 2,616 (2.8) | 5,471 (2.5) | 7,139 (3.0) |
| Length of Stay, days | |||
| Median (25th, 75th) | 4 (2 – 6) | 4 (2 – 6) | 4 (2 – 6) |
| Mean (SD) | 4.5 (4.0) | 4.9 (4.5) | 5.0 (4.9) |
| 30-day Endpoints * | |||
| All-cause mortality | 890 (5.7) | 2,192 (6.2) | 2,448 (6.5) |
| All-cause readmission | 3,402 (22.0) | 7,674 (21.6) | 8,352 (22.1) |
| HF readmission | 1,407 (9.1) | 3,219 (9.1) | 3,466 (9.2) |
| Mortality or HF readmission | 2,113 (13.6) | 4,995 (14.0) | 5,464 (14.4) |
| 12-month Endpoints * | |||
| All-cause mortality | 5,703 (36.73) | 12,751 (35.80) | 13,872 (36.55) |
| All-cause readmission | 10,114 (66.16) | 22,497 (64.23) | 24,236 (64.90) |
| HF readmission | 5,374 (35.23) | 11,660 (33.37) | 12,406 (33.29) |
| Mortality or HF readmission | 8,586 (55.30) | 19,019 (53.40) | 20,518 (54.06) |
*
For in-hospital outcomes, the denominators used for the three groups were 92,249, 221,730 and 241,057 respectively. For 30-day and 12-month outcome analyses, the demoniators for the three groups were 15,527, 35,614, and 37,952. #FDA= Food and Drug Administration; GWTG= Get With The Guidelines; HFrEF= Heart Failure with Reduced Ejection Fraction; SD= Standard Deviation; HF= Heart Failure.