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Inflammatory cytokine production specific to T cells is attenuated in mice deficient in CD4+ or CD8+ T cells in response to modified Ti implants. Cytokine analysis of peri-implant tissue from either WT, Cd4−/−, Cd8−/− mice at 3-, 7-, and 14-days post-implantation (n=6). p<0.05: A vs. WT, B vs. Cd4−/−, # vs. smooth Ti, $ vs. rough Ti.
