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Secreted cytokines, proteins, and growth factors within the conditioned media from macrophage-T cell coculture experiments are altered by the deficiency of CD4+ or CD8+ T cells in response to modified Ti. Protein analysis of the conditioned media from macrophages cultured with T cells from either WT, Cd4−/−, or Cd8−/− mice (n=6). p<0.05: A vs. WT, B vs. Cd4−/−, # vs. smooth Ti, $ vs. rough Ti.
