Table 6.
Regulatory Networks of MIR17HG and its associated ncRNAs in CRC oncogenesis
| LncRNA/miRNA | Downstream target | Outcomes in CRC cells | Cell line | Refs. |
|---|---|---|---|---|
| MIR17HG | hsa-miR-375/NF-κB/RELA | Enhance invasion and metastasis of CRC cells | HCT116, SW620 | [15] |
| hsa-miR-138-5p/HK1 | Enhance invasion of CRC cells / Increase liver metastasis | SW480, RKO | [54] | |
| hsa-miR-17 | MFN2 | Resistance to 5-FU | HCT116 | [55] |
| BLINK | Enhance migration and invasion of CRC cells | SW620, HCT116 | [15] | |
| PTEN | Metastatic behavior and multiple drug resistance | SW480, HCT116 | [56] | |
| RUNX3 | Enhance CRC metastasis | SW480, HCT116 | [57] | |
| CYLD | Resistance to 5-FU | T84 | [58] | |
| VIM | Decrease migration and invasion of CRC cells | LoVo, HT29 | [59] | |
| P130 | Increase proliferation and invasion / Decrease apoptosis | SW480, LoVo | [60] | |
| PLCD1 | Reduce apoptosis, and increase invasion and migration of CRC cells | LoVo, HCT116 | [61] | |
| GABBR1 | Promote invasion and proliferation of CRC cells | HCT116, HT29 | [62] | |
| hsa-miR-19a | TIA1 | Increase CRC cell invasion and proliferation | SW480 | [63] |
| CLCA4 | Promote invasion, proliferation, and migration of CRC cells | CaCo2, SW480 | [64] | |
| FOXF2 | Increase CRC cell proliferation and migration | HCT116 | [65] | |
| THBS1 | Increase viability and migration of CRC cells | SW480 | [66] | |
| PTEN | Enhance CRC cell migration and invasion | HCT116, SW480 | [67] | |
| KRAS | Decrease angiogenesis of CRC cells | HCT116 | [68] | |
| hsa-miR-19b-1 | ACSL/SCD | Impede invasion of CRC cells | SW620 | [69] |
| hsa-miR-18a | CDC42 | Reduce proliferation, and migration /Enhance apoptosis of CRC cells | HCT116, LIM1215 | [70] |
| TBPL1 | Suppress growth, migration, and invasion of CRC cells | HCT116, SW620 | [71] | |
| ULK1 | Reduce autophagy activation/ Reduce Chemoresistance in CRC cells | HCT116 | [72] | |
| ATM | Reduce DNA double-strand breaks repair | HCT116 | [73] | |
| hsa-miR-20a | BID | Reduce apoptosis of CRC cells | SW480 | [74] |
| MICA | Reduce CRC cell sensitivity to NK cells | SW480, HCT116 | [75] | |
| FOXJ2 | Increase proliferation, invasion, and migration of CRC cells | HCT116 | [76] | |
| SMAD4 | Induce EMT / increase proliferation and invasion of CRC cells | SW480 | [77] | |
| POCD4 | Increase CRC cells proliferation / Resistance to 5-FU | SW480, HCT116 | [78] | |
| ATG5/FIP200 | Inhibit the autophagic response initiated by hypoxia | LoVo, SW480 | [79] |