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. 2024 Apr 26;9:103. doi: 10.1038/s41392-024-01810-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — LPHN1 is present on hypothalamic neurons that regulate feeding behavior. a Meta-analysis of RNA-seq data from⁴⁵ revealed expression of all three latrophilin homologs in mouse AGRP- and POMC neurons. The mRNA levels of Lphn1 and Lphn3 are comparable to those of some GPCRs (Gshr and Npy1R–Npy6R) known to be involved in the regulation of food intake. Eltd1, the fourth member of this aGPCR group, is not expressed. Given are mean transcript per million mapped reads (TPM) values ± SD of five individuals. b The expression levels of neuronal components involved in the regulation of food intake are not altered in obese Lphn1-deficient mice. The hypothalamus of 30–34-week-old mice were subjected to qPCR analysis using gene-specific primers for prohormone convertase 1 (gene Pcsk1), prohormone convertase 2 (gene Pcsk2), the orexigenic neuropeptides NPY, AGRP, galanin (gene Gal), pro melanin concentrating hormone (gene Pmch), and hypocretin (gene Hcrt) as well as the anorexigenic neuropeptides POMC, Cart, neurotensin (gene Nts), cholecystokinin (gene Cck), and oxytocin (gene Oxt). Data are given as means ± SD; n ≥ 3 normalized to β-microglobulin/-actin (20.60 ± 2.33)