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. 2024 Apr 25;15:3528. doi: 10.1038/s41467-024-47847-8

Fig. 7. BIN1 knockdown improves cardiac contractility in old mice.

Fig. 7

a Representative M-mode echocardiogram images from conscious young and old mice. b Summary dot-plots showing fractional shortening (FS) in young (N = 10) and old (N = 30) mice are shown. c, d Representative M-mode echocardiogram images from conscious old mice before and two, four, and six weeks after RO-injection of shRNA-scrmb (c) and shRNA-mBIN1 (d). e Summary dot-plots for FS showing paired results before and two weeks after RO-injection for shRNA-scrmb (N = 14) and shRNA-mBIN1 (N = 14). f summary dot-plots for FS showing paired results before and two, four, and six weeks after RO-injection for shRNA-scrmb (N = 5) and shRNA-mBIN1 (N = 5). Statistical analysis was performed on data in (b) using unpaired two-tailed Student’s t-tests, on data in (e) using paired two-tailed Student’s t-tests, and on data in (f ) using one-way ANOVAs with multiple comparison post-hoc tests. Young data are from NIA young mice. Data are presented as mean ± SEM. Source data are provided in the Source Data file.