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. 2024 Apr 25;15:3502. doi: 10.1038/s41467-024-47594-w

Fig. 2. Relative abundance of the gut commensal Blautia correlates with mucus function.

Fig. 2

A Weighted UniFrac PCoA and (B) relative abundance of bacterial genera before (baseline) and after (termination) human-to-mouse FMT. C Abundance of bacterial taxa in fresh stool samples from mice transplanted with habitual diet (HD)- or high-fiber diet (HF)-derived human microbiota and fed a chow or Western-style diet (WSD) at phylum and (D) genus level (n = 8 mice/group). Relative abundance taxa plots (left) display the top 30 bacterial taxa. Boxplots (right) display Centered log-ratio (CLR) transformed abundance counts of selected taxa, with data presented as median with upper and lower quartiles. Statistical significance was determined by 2-way ANOVA and Tukey’s multiple comparison test. E Spearman correlation analysis between mucus growth rate in the distal colon and centered log ratio (Clr)-transformed relative abundance of selected genera. Data was tested for normal distribution using the D’Agostino & Pearson test and P values were adjusted for multiple comparisons using the Benjamini‒Hochberg procedure. For adjusted P values in (D) and (E), p(adj) < 0.05 (*), p(adj) < 0.01 (**), p(adj) < 0.001 (***) and p(adj) < 0.0001 (****) were considered statistically significant. F Relative abundance of Blautia in human participants (n = 67) before and after 12 weeks of high-fiber intervention. Data is presented as mean ± SD and statistical significance was determined by the Wilcoxon matched-pairs signed-rank test, with p < 0.05 (*) considered statistically significant. All P values are two-sided. Source data are provided as a Source Data file.