Table 1.

Most enriched GO terms in RNS secretomes: biological process, molecular function, cellular component.

	Name	p value	Genes from input	Genes in annotation
Biological process
GO:0030198	Extracellular matrix organization	1.85e–26	24	3338
GO:0010810	Regulation of cell-substrate adhesion	5.96e–09	11	212
GO:0051093	Negative regulation of developmental process	5.96e–09	18	983
GO:0051241	Negative regulation of multicellular organismal process	1.32e–08	19	1231
GO:0009611	Response to wounding	1.63e–08	14	532
GO:0042060	Wound healing	2.17e–08	13	439
GO:0030155	Regulation of cell adhesion	4.04e–08	15	712
GO:0032963	Collagen metabolic process	2.41e–07	7	63
GO:0050793	Regulation of developmental process	2.41e–07	24	2448
GO:0030334	Regulation of cell migration	4.25e–07	15	865
Molecular function
GO:0005201	Extracellular matrix structural constituent	6.76e–17	14	119
GO:0005198	Structural molecule activity	2.90e–11	17	635
GO:0005518	Collagen binding	3.32e–07	7	68
GO:0061134	Peptidase regulator activity	1.74e–06	9	226
GO:0030020	Extracellular matrix structural constituent conferring tensile strength	6.59e–06	5	28
GO:0005539	Glycosaminoglycan binding	3.77e–05	8	240
GO:0050840	Extracellular matrix binding	0.00011	5	56
GO:0002020	Protease binding	0.00032	6	138
GO:0004866	Endopeptidase inhibitor activity	0.00098	6	181
GO:0004867	Serine-type endopeptidase inhibitor activity	0.00098	5	98
Cellular component
GO:0031012	Extracellular matrix	3.29e–35	31	527
GO:0062023	Collagen-containing extracellular matrix	1.88e–31	27	396
GO:0005576	Extracellular region	2.42e–23	42	4166
GO:0005615	Extracellular space	1.57e–21	38	3195
GO:1903561	Extracellular vesicle	3.62e–13	27	2121
GO:0005788	Endoplasmic reticulum lumen	1.40e–12	14	308
GO:0005604	Basement membrane	6.24e–12	10	96
GO:0070062	Extracellular exosome	2.19e–11	25	2099
GO:0031982	Vesicle	9.84e–11	31	3879
GO:0005581	Collagen trimer	9.72e–06	6	88

Selection based on p-value. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by String.dg.org is shown in Supplementary Tables S3 and S4.