Table 3.

Most enriched GO terms in RNS-1 cellular proteome concerning extracellular matrix cluster: biological process, molecular function, cellular component.

	Name	pValue	Genes from input	Genes in annotation
Biological process
GO:0009653	Anatomical structure morphogenesis	8.11e–11	18	2165
GO:0022610	Biological adhesion	1.84e–10	14	931
GO:0048646	Anatomical structure formation involved in morphogenesis	2.19e–09	13	883
GO:0007155	Cell adhesion	2.94e–09	13	925
GO:0030198	Extracellular matrix organization	9.71e–08	9	338
GO:0048856	Anatomical structure development	1.93e–07	20	5402
GO:0031589	Cell-substrate adhesion	1.03e–06	7	182
GO:0001525	Angiogenesis	1.09e–06	8	315
GO:0030154	Cell differentiation	1.67e–06	17	3702
GO:0016043	Cellular component organization	3.23e–06	19	5447
Molecular function
GO:0005178	Integrin binding	7.04e–15	11	147
GO:0050839	Cell adhesion molecule binding	2.66e–14	14	538
GO:0044877	Protein-containing complex binding	3.01e–08	13	1216
GO:0005102	Signaling receptor binding	5.80e–07	13	1581
GO:0005518	Collagen binding	0.00062	4	68
GO:0005515	Protein binding	0.0021	18	7026
GO:0005201	Extracellular matrix structural constituent	0.0038	4	119
GO:0050840	Extracellular matrix binding	0.0134	3	56
GO:0005198	Structural molecule activity	0.0141	6	635
GO:0098634	Cell–matrix adhesion mediator activity	0.0141	2	7

	Name	pValue	Genes from input	Genes in annotation
GO:0005925	Focal adhesion	4.69e–14	13	405
GO:0005576	Extracellular region	9.58e–08	18	4166
GO:0009897	External side of plasma membrane	1.92e–07	8	331
GO:0098552	Side of membrane	2.67e–07	9	531
GO:0009986	Cell surface	5.19e–07	10	824
GO:0031252	Cell leading edge	2.29e–05	7	425
GO:0031012	Extracellular matrix	8.97e–05	7	527
GO:0030027	Lamellipodium	0.00021	5	202
GO:0062023	Collagen-containing extracellular matrix	0.00026	6	396
GO:0034668	Integrin alpha4-beta1 complex	0.00088	2	3

Selection based on p-value. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by String.dg.org is shown in Supplementary Tables S11 and S12.