Table 4.

Most enriched GO terms in RNS-1 cellular proteome concerning the actin cytoskeleton cluster: biological process, molecular function, cellular component.

	Name	p value	Genes from input	Genes in annotation
Biological process
GO:0007015	Actin filament organization	1.39e–13	10	254
GO:0008154	Actin polymerization or depolymerization	4.50e–07	5	57
GO:1902743	Regulation of lamellipodium organization	3.65e–05	4	47
GO:0030042	Actin filament depolymerization	0.00010	3	11
GO:0006928	Movement of cell or subcellular component	0.00065	8	1501
GO:0010591	Regulation of lamellipodium assembly	0.0016	3	35
GO:0032956	Regulation of actin cytoskeleton organization	0.0016	5	348
GO:1902745	Positive regulation of lamellipodium organization	0.0016	3	33
GO:0120032	Regulation of plasma membrane bounded cell projection assembly	0.0029	4	181
GO:0008064	Regulation of actin polymerization or depolymerization	0.0030	4	189
Molecular function
GO:0003779	Actin binding	7.31e–12	10	438
GO:0051015	Actin filament binding	1.05e–10	8	199
GO:0005515	Protein binding	0.0030	12	7026
Component
GO:0015629	Actin cytoskeleton	4.12e–14	11	477
GO:0070161	Anchoring junction	2.39e–06	8	820
GO:0005925	Focal adhesion	2.91e–05	6	405
GO:0030027	Lamellipodium	2.91e–05	5	202
GO:0032432	Actin filament bundle	2.91e–05	4	73
GO:0043292	Contractile fiber	4.43e–05	5	238
GO:0005884	Actin filament	5.87e–05	4	101
GO:0070062	Extracellular exosome	5.87e–05	9	2099
GO:0005938	Cell cortex	7.37e–05	5	292
GO:0031982	Vesicle	0.00042	10	3879

Selection based on p-value. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by String.dg.org is shown in Supplementary Tables S11 and S12.