Table 5.

Most enriched GO terms in RNS-2 cellular proteome concerning actin cytoskeleton cluster: biological process, molecular function, cellular component.

	Name	pValue	Genes from Input	Genes in Annotation
Biological process
GO:0030029	Actin filament-based process	1.96e–12	13	592
GO:0030036	Actin cytoskeleton organization	1.34e–11	12	516
GO:0007015	Actin filament organization	2.32e–09	9	254
GO:0097435	Supramolecular fiber organization	1.03e–08	10	480
GO:0032970	Regulation of actin filament-based process	7.50e–05	7	390
GO:0030048	Actin filament-based movement	0.00015	5	121
GO:0034329	Cell junction assembly	0.00024	6	280
GO:0034330	Cell junction organization	0.00024	7	493
GO:0051017	Actin filament bundle assembly	0.00028	4	55
GO:0000904	Cell morphogenesis involved in differentiation	0.00046	7	566
Molecular function
GO:0003779	Actin binding	5.72e–19	15	438
GO:0008092	Cytoskeletal protein binding	3.59e–16	16	973
GO:0050839	Cell adhesion molecule binding	3.67e–12	12	538
GO:0045296	Cadherin binding	4.40e–09	9	334
GO:0051015	Actin filament binding	4.40e–09	8	199
GO:0005515	Protein binding	0.00018	17	7026
GO:0044877	Protein-containing complex binding	0.00019	9	1216
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	0.00034	4	78
GO:0003785	Actin monomer binding	0.0010	3	28

	Name	pvalue	Genes from input	Genes in annotation
GO:0005925	Focal adhesion	9.53e–20	15	405
GO:0015629	Actin cytoskeleton	4.18e–15	13	477
GO:0030016	Myofibril	6.80e–15	11	227
GO:0005856	Cytoskeleton	2.37e–11	16	2221
GO:0099512	Supramolecular fiber	4.30e–10	12	939
GO:0030017	Sarcomere	1.14e–09	8	207
GO:0001725	Stress fiber	4.65e–09	6	65
GO:0005903	Brush border	5.36e–08	6	106
GO:0030018	Z disc	1.72e–07	6	131
GO:0005938	Cell cortex	4.02e–07	7	292

Selection based on p-value. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by String.dg.org is shown in Supplementary Tables S13 and S14.