Table 6.

Most enriched GO terms in RNS-2 cellular proteome concerning ECM cluster: biological process, molecular function, cellular component.

	Name	pvalue	Genes from input	Genes in annotation
Biological process
GO:0030198	Extracellular matrix organization	2.91e–05	6	338
GO:0030199	Collagen fibril organization	2.91e–05	4	46
GO:0060351	Cartilage development involved in endochondral bone morphogenesis	2.91e–05	4	43
GO:0060348	Bone development	3.66e–05	5	199
GO:0001501	Skeletal system development	4.82e–05	6	499
GO:0003429	Growth plate cartilage chondrocyte morphogenesis	0.00011	3	17
GO:0009887	Animal organ morphogenesis	0.00061	6	967
GO:0032963	Collagen metabolic process	0.0014	3	63
GO:0071230	Cellular response to amino acid stimulus	0.0017	3	69
GO:0001503	Ossification	0.0018	4	265
Molecular function
GO:0030020	Extracellular matrix structural constituent conferring tensile strength	4.02e–09	5	28
GO:0019798	Procollagen-proline dioxygenase activity	8.69e–06	3	7
GO:0048407	Platelet-derived growth factor binding	1.97e–05	3	11
GO:0031418	L-ascorbic acid binding	6.39e–05	3	20
GO:0004656	Procollagen-proline 4-dioxygenase activity	0.0011	2	4
GO:0005506	Iron ion binding	0.0077	3	147

	Name	pvalue	Genes from input	Genes in annotation
GO:0005788	Endoplasmic reticulum lumen	6.37e–11	8	308
GO:0005581	Collagen trimer	7.36e–10	6	88
GO:0062023	Collagen-containing extracellular matrix	3.26e–06	6	396
GO:0005584	Collagen type I trimer	0.00032	2	2
GO:0005589	Collagen type VI trimer	0.00046	2	3

Selection based on p-value. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by String.dg.org is shown in Supplementary Tables S13 and S14.