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. 2024 Apr 12;15:1330228. doi: 10.3389/fimmu.2024.1330228

Figure 2.

Figure 2

AhR expression patterns in head and neck squamous cell carcinoma (HNSCC). (A) Heatmap summarizing the AhR expression and localization in cancer/epithelial cells, T cells, macrophages, and Tregs in normal and malignant head and neck tissues (N = 80). (B) AhR expression in cancer cells in malignant head and neck tissues with varying cancer grades. (C) Representative images of AhR-expressing (AhR+) and non-AhR-expressing (AhR-) head and neck cancer cells, along with AhR-expressing immune cells, including macrophages, T cells, and Tregs. (D) AhR expression in the cytosol was positively correlated with that in the nucleus (P < 0.0001). (E) AhR expression in T cells (T), macrophages (M), and Tregs in the stroma (ST) and tumor nest (TN). (F) Correlation plot showing no significant correlation between AhR expression in the cancer cell nucleus and the TAM infiltration degree in the tumor nest (TN)(P = 0.0514). (G) Correlation plot showing no significant correlation between AhR expression in the cancer cell nucleus and the T-cell infiltration degree in the TN. *P < 0.05; **P < 0.01.