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. 2024 Apr 12;15:1330228. doi: 10.3389/fimmu.2024.1330228

Figure 3.

Figure 3

AhR expression patterns in bladder cancer. (A) Heatmap summarizing the AhR expression and localization in cancer/epithelial cells, T cells, macrophages, and Tregs in normal and malignant bladder tissues (N = 48). (B) AhR expression in malignant bladder tissues of varying cancer stages. (C) Representative images of AhR-expressing (AhR+) and non-AhR-expressing (AhR-) bladder cancer cells, along with AhR-expressing immune cells, including macrophages, T cells, and Tregs. (D) AhR expression in the cytosol is positively correlated with the nuclear AhR expression (P < 0.0001). (E) AhR expression in T cells (T), macrophages (M), and Tregs in the stroma (ST) and tumor nest (TN). (F) Correlation plot showing no significant correlation between AhR expression in cancer cell nucleus and the TAM infiltration degree in the TN(P = 0.0562). (G) Correlation plot showing no significant correlation between the AhR expression in cancer cell nucleus and the T-cell infiltration degree in the TN. N.S., no significant difference, *P < 0.05, ***P < 0.001.