Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 12;14:1371934. doi: 10.3389/fonc.2024.1371934

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Le, Choi, Han, Kim, Trinh, Kim and Ryu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

APOL1 suppression activates Akt signaling pathway in clear cell renal cell carcinoma. (A) GSEA of RNA-seq data from patient ccRCC tumors compared to their adjacent normal tissues. (B) Gene enrichment analysis of 212 upregulated genes in patient ccRCC tumors. (C, D) Western blot analysis of Akt, NFĸB, GSK3β protein in control and APOL1 knockdown/overexpressing renal cells (C), and miR-30a transfected A-498 and 786-O cells (D). (E) Western blot analysis of focal adhesion proteins in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. (F) Western blot analysis of EMT markers in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. Actin served as an internal control.