Figure 3.

Deletion of A20 in myeloid cells hampers Th2 immunity and promotes Th1 response upon Trichuris muris infection. (A, B) Flow cytometry analysis of colon lamina propria of WT (n = 6) and A20^myel-KO (n = 4) mice infected with T. muris for the myeloid and (C, D) T-cell composition, presented in t-SNE plots (upper panels) and bar graphs (lower panels). (E) MACSima fluorescent imaging for CD45 (yellow), CD11b (green), and CD64 (magenta) of WT and A20^myel-KO colon sections at steady state and upon infection with T. muris for 21 days. Scale bar 100 μm. * p<0,05, ** p<0,01, *** p<0,001, **** p < 0.0001.